Description
Biostatistician
PYC Therapeutics
Nedlands WA (on-site)
Full time Job title: Biostatistician
Job Description
Life-changing science is our focus; we start there, and everything else follows.
As we enter 2026, we are at a transformative inflection point. With a proprietary drug delivery platform and a maturing pipeline of first-in-class RNA therapies, we aretransitioning from a clinical explorer to a globally recognized biotech leader. Our pipeline includes two clinical programs for Inherited Retinal Diseases, one focusing on Polycystic Kidney Disease and a fourth pre-clinical program on Phelan-McDermid Syndrome.
We are seeking a Biostatistician to join our growing Bioinformatics & Data Analytics team. Working alongside our Technical Lead Biostatistics, you will help ensure that every analysis — from early exploratory work to investor-facing data disclosures — meets the highest standards of statistical integrity. This is a hands-on role for someone who thrives on rigorous methodology and wants to see their work directly shape the development of life-changing medicines.
Only candidates with ongoing unrestricted rights to work in Australia will be considered.
Please note: The position may close earlier than stated once a successful candidate is identified.
Selection Criteria
Required
• Postgraduate degree in statistics, biostatistics, mathematics or a related quantitative discipline.
• 5+ years of applied biostatistics experience, ideally within the life-science, biotech or pharmaceutical sector.
• Solid grounding in Frequentist and Bayesian statistics, longitudinal data modeling, and mixed-effects models.
• Experience analyzing clinical or translational datasets, including safety, efficacy, PK/PD or biomarker endpoints.
• Proficient in statistical programming languages, preferably R; comfortable working with large, complex datasets.
• Ability to design, execute, and interpret analyses with a high degree of independence.
• Strong communication skills with the ability to present statistical findings clearly to non-technical audiences.
Desirable
• Experience in rare disease, ophthalmology, RNA therapeutics, or genetic medicine settings.
• Familiarity with regulatory statistical expectations (e.g. ICH guidelines, FDA/EMA submissions).
• Experience with adaptive trial designs, dose-finding models or interim analysis frameworks.
• Exposure to simulation-based approaches, predictive modelling, or decision analytic methods.
• Proficiency in additional tools such as Python or Stan.
• Proficiency in reproducible analysis using tools such as Git
• Experience contributing to statistical analysis plans (SAPs) or clinical study protocols.
• Exposure to real-world evidence (RWE) or natural history study data.
• Publication record in peer-reviewed journals demonstrating applied biostatistical expertise.
Key responsibilities
Data Analysis & Interpretation
• Analyze clinical and translational datasets across PYC's programs, including biomarker, PK/PD, safety and efficacy data.
• Design and implement appropriate statistical approaches to support meaningful interpretation of study outcomes across development phases (e.g. Phase 1/2 clinical trials).
• Perform exploratory and confirmatory analyses — including Bayesian models, simulations and predictive modelling — to support data-driven decision-making.
• Prepare clear, accurate statistical summaries, visualizations and interpretations tailored to executive, clinical, and investor audiences.
• Collaborate closely with pre-clinical, clinical, bioinformatics and data analytics teams to ensure analyses are aligned with program objectives.
Statistical Design & Consultation
• Assist in the design of analysis plans and data presentation strategies for ongoing and upcoming clinical and nonclinical studies.
• Provide statistical input into study planning, endpoint selection, data summarization and interpretation frameworks.
• Advise internal teams on experimental design, sample size considerations, and appropriate statistical methodologies.
• Contribute to internal review of data packages and external-facing materials to ensure interpretations are statistically robust and defensible.
Technical & Organizational Excellence
• Ensure all analyses and outputs adhere to best practices for version control, documentation and reproducibility.
• Support statistical literacy across the organization, contributing to the mentoring of colleagues on core statistical concepts.
• Communicate complex statistical concepts to diverse stakeholders, adjusting to their level of expertise.
About PYC
PYC Therapeutics (ASX: PYC) is a clinical-stage biotechnology company creating a new generation of RNA therapies to change the lives of patients with genetic diseases. The Company utilises its proprietary drug delivery platform to enhance the potency of precision medicines within the rapidly growing and commercially proven RNA therapeutics class.
PYC's drug development programs target monogenic diseases – the indications with the highest likelihood of success in clinical development. The Company has three clinical stage programs with a fourth due to enter the clinic in 2027. Now is an incredibly exciting time to join PYC with high-value human data readouts expected across all three clinical trial programs throughout 2025 and 2026 and a funding runway that extends to CY2030. PYC is an Australian listed company with offices in Perth and Sydney, Australia and San Francisco Bay Area.
